Issue 7, 2005

Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism

Abstract

The introduction of two mutations (G74C/C188S) based on the estimated reaction mechanism resulted in the inversion of enantioselectivity of arylmalonate decarboxylase, which catalyses the asymmetric decarboxylation of arylmethylmalonate to give optically active arylpropionate.

Graphical abstract: Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism

Supplementary files

Article information

Article type
Communication
Submitted
25 Oct 2004
Accepted
19 Nov 2004
First published
10 Jan 2005

Chem. Commun., 2005, 877-879

Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism

Y. Ijima, K. Matoishi, Y. Terao, N. Doi, H. Yanagawa and H. Ohta, Chem. Commun., 2005, 877 DOI: 10.1039/B416398B

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