Issue 7, 2005
From the journal:

Chemical Communications

Selective polymorph transformation viasolvent-drop grinding†

Andrew V. Trask,a   Ning Shan,*b   W. D. Samuel Motherwell,c   William Jones,*a   Shaohua Feng,b   Reginald B. H. Tanb  and  Keith J. Carpenterb  

* Corresponding authors

a Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: wj10@cam.ac.uk
Fax: +44 1223 336362
Tel: +44 1223 336468

b Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore
E-mail: shan_ning@ices.a-star.edu.sg
Fax: +65 6873 4805
Tel: +65 6796 3865

c Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, UK

Abstract

A method of inducing specific polymorph transformations is exemplified with two single-component systems, whereby a given crystal form undergoes conversion when subjected to solid state grinding in the presence of a minor quantity of a certain solvent.

Graphical abstract: Selective polymorph transformation via solvent-drop grinding

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Article information

DOI
https://doi.org/10.1039/B416980H
Article type
Communication
Submitted
09 Nov 2004
Accepted
08 Dec 2004
First published
19 Jan 2005

Chem. Commun., 2005, 880-882

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Selective polymorph transformation via solvent-drop grinding

A. V. Trask, N. Shan, W. D. S. Motherwell, W. Jones, S. Feng, R. B. H. Tan and K. J. Carpenter, Chem. Commun., 2005, 880 DOI: 10.1039/B416980H

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