Issue 11, 2005
From the journal:

Chemical Communications

Asymmetric direct aldol reaction catalyzed by an l-prolinamide derivative: considerable improvement of the catalytic efficiency in the ionic liquid†

Hai-Ming Guo,ab   Lin-Feng Cun,a   Liu-Zhu Gong,*a   Ai-Qiao Mia  and  Yao-Zhong Jiang*a  

* Corresponding authors

a Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China
E-mail: gonglz@cioc.ac.cn

b Department of Chemistry, Henan Normal University, Xinxiang, Henan, China

Abstract

The asymmetric direct aldol reactions of a wide scope of aldehydes with unmodified ketones in the presence of 20 mol% (S,S,S)-pyrrolidine-2-carboxylic acid (2′-hydroxyl-1′,2′-diphenyl-ethyl)-amine (1) were performed in ionic liquids; aldol products with 91 to >99% ees for aromatic aldehydes and 99% ees for alphatic aldehydes were offered by the present procedure.

Graphical abstract: Asymmetric direct aldol reaction catalyzed by an l-prolinamide derivative: considerable improvement of the catalytic efficiency in the ionic liquid

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Article information

DOI
https://doi.org/10.1039/B417267A
Article type
Communication
Submitted
12 Nov 2004
Accepted
21 Dec 2004
First published
21 Jan 2005

Chem. Commun., 2005, 1450-1452

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Asymmetric direct aldol reaction catalyzed by an L-prolinamide derivative: considerable improvement of the catalytic efficiency in the ionic liquid

H. Guo, L. Cun, L. Gong, A. Mi and Y. Jiang, Chem. Commun., 2005, 1450 DOI: 10.1039/B417267A

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