Issue 29, 2005

An exploration of the polymorphism of piracetam using high pressure

Abstract

High-pressure recrystallisation of aqueous and methanolic solutions of piracetam (2-oxo-pyrrolidineacetamide) contained in a diamond-anvil cell at pressures of 0.07–0.4 GPa resulted in the formation of a new high-pressure polymorph of piracetam that has been characterised by in situ X-ray diffraction. The molecular packing arrangement of the new form is very different from those of forms I, II, and III, and the piracetam molecules also adopt a very different conformation in this new phase. Depressurisation to ambient pressure resulted in the formation of form II via a single-crystal to single-crystal transition. By contrast, crystallisation of piracetam from water at ambient pressure resulted in the formation of a new monohydrate of piracetam, which has been characterised by single crystal X-ray diffraction.

Graphical abstract: An exploration of the polymorphism of piracetam using high pressure

Supplementary files

Article information

Article type
Paper
Submitted
17 Dec 2004
Accepted
23 Feb 2005
First published
04 Mar 2005

CrystEngComm, 2005,7, 179-186

An exploration of the polymorphism of piracetam using high pressure

F. P. A. Fabbiani, D. R. Allan, S. Parsons and C. R. Pulham, CrystEngComm, 2005, 7, 179 DOI: 10.1039/B418976K

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