Issue 20, 2005

Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

Abstract

We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.

Graphical abstract: Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

Article information

Article type
Communication
Submitted
20 Dec 2004
Accepted
17 Feb 2005
First published
11 Mar 2005

Chem. Commun., 2005, 2552-2554

Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

F. M. Brunel and P. E. Dawson, Chem. Commun., 2005, 2552 DOI: 10.1039/B419015G

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