Issue 6, 2005

Behaviour and design considerations for continuous flow closed-open-closed liquid microchannels

Abstract

This paper introduces a method of combining open and closed microchannels in a single component in a novel way which couples the benefits of both open and closed microfluidic systems and introduces interesting on-chip microfluidic behaviour. Fluid behaviour in such a component, based on continuous pressure driven flow and surface tension, is discussed in terms of cross sectional flow behaviour, robustness, flow-pressure performance, and its application to microfluidic interfacing. The closed-open-closed microchannel possesses the versatility of upstream and downstream closed microfluidics along with open fluidic direct access. The device has the advantage of eliminating gas bubbles present upstream when these enter the open channel section. The unique behaviour of this device opens the door to applications including direct liquid sample interfacing without the need for additional and bulky sample tubing.

Graphical abstract: Behaviour and design considerations for continuous flow closed-open-closed liquid microchannels

Article information

Article type
Paper
Submitted
03 Feb 2005
Accepted
07 Apr 2005
First published
21 Apr 2005

Lab Chip, 2005,5, 682-686

Behaviour and design considerations for continuous flow closed-open-closed liquid microchannels

J. Melin, W. van der Wijngaart and G. Stemme, Lab Chip, 2005, 5, 682 DOI: 10.1039/B501781E

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