Issue 19, 2005
From the journal:

Chemical Communications

DNA mismatch detection using a pyrene–excimer-forming probe†‡

Kazushige Yamana,*a   Yudai Fukunaga,a   Yusuke Ohtani,a   Sayaka Sato,a   Mitsunobu Nakamura,a   Won Jong Kim,b   Toshihiro Akaikeb  and  Atsushi Maruyamac  

* Corresponding authors

a Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2201, Japan
E-mail: yamana@eng.u-hyogo.ac.jp
Fax: 81-792-67-4895

b Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuda, Midori-Ku, Yokohama 226-8501, Japan

c Institute for Materials Chemistry and Engineering, Kyushu University and CREST of JST, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
E-mail: maruyama@ms.ifoc.kyushu-u.ac.jp

Abstract

A pyrene–excimer-forming probe allowed the easy and sensitive detection of a single base mismatch in target DNA. This was due to the faster strand exchange rate compared to a fully-matched target.

Graphical abstract: DNA mismatch detection using a pyrene–excimer-forming probe

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Article information

DOI
https://doi.org/10.1039/B502033F
Article type
Communication
Submitted
10 Feb 2005
Accepted
11 Mar 2005
First published
01 Apr 2005

Chem. Commun., 2005, 2509-2511

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DNA mismatch detection using a pyrene–excimer-forming probe

K. Yamana, Y. Fukunaga, Y. Ohtani, S. Sato, M. Nakamura, W. J. Kim, T. Akaike and A. Maruyama, Chem. Commun., 2005, 2509 DOI: 10.1039/B502033F

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