Issue 9, 2005

Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

Abstract

Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O–O bond are presented.

Graphical abstract: Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2005
Accepted
16 Mar 2005
First published
04 Apr 2005

Org. Biomol. Chem., 2005,3, 1612-1614

Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

F. Najjar, L. Gorrichon, M. Baltas, C. André-Barrès and H. Vial, Org. Biomol. Chem., 2005, 3, 1612 DOI: 10.1039/B503402G

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