Thioctic acid amides: convenient tethers for achieving low nonspecific protein binding to carbohydrates presented on gold surfaces

Abstract

The thioctic acid amides of 2′-aminoethyl α-D-mannopyranoside and 2′-aminoethyl α-1,3-D-mannopyranosyl (α-1,6-D-mannopyranosyl)-α-D-mannopyranoside presented on both planar and nanoparticle gold surfaces give higher specific and lower non-specific protein binding than the related 2′-thioethyl glycosides.