Issue 37, 2005
From the journal:

Chemical Communications

Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities†

Dik-Lung Ma,a   Tina Yuen-Ting Shum,a   Fuyi Zhang,a   Chi-Ming Che*a  and  Mengsu Yangb  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +852 2857-1586
Tel: +852 2859 2154

b Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong

Abstract

Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

Graphical abstract: Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

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Article information

DOI
https://doi.org/10.1039/B507114C
Article type
Communication
Submitted
19 May 2005
Accepted
30 Jun 2005
First published
23 Aug 2005

Chem. Commun., 2005, 4675-4677

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Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

D. Ma, T. Y. Shum, F. Zhang, C. Che and M. Yang, Chem. Commun., 2005, 4675 DOI: 10.1039/B507114C

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