Issue 37, 2005
From the journal:

Chemical Communications

Nickel-catalyzed four-component connection of oraganoaluminium (organozinc), isoprene, aldehydes and amines: stereo- and regioselective synthesis of trisubstituted (E)-homoallylamines†

Keisuke Kojima,a   Masanari Kimuraa  and  Yoshinao Tamaru*b  

* Corresponding authors

a Graduate School of Science and Technology, Nagasaki University, 1-14 Bunkyo, Nagasaki 852-8521, Japan
E-mail: masanari@net.nagasaki-u.ac.jp

b Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 1-14 Bunkyo, Nagasaki 852-8521, Japan
E-mail: tamaru@net.nagasaki-u.ac.jp
Fax: +95-819-2677
Tel: +95-819-2677

Abstract

Ni(acac)2 catalyzes the four-component connection reaction of trimethylaluminium (or diphenylzinc), isoprene, aromatic aldehydes and p-anisidine in this order and provides (E)-1-aryl-1-(p-methoxyphenyl)amino-3-methyl-3-hexenes (or (E)-1-aryl-1-(p-methoxyphenyl)amino-3-methyl-5-phenyl-3-pentenes) selectively in good yield.

Graphical abstract: Nickel-catalyzed four-component connection of oraganoaluminium (organozinc), isoprene, aldehydes and amines: stereo- and regioselective synthesis of trisubstituted (E)-homoallylamines

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Article information

DOI
https://doi.org/10.1039/B507229H
Article type
Communication
Submitted
24 May 2005
Accepted
01 Aug 2005
First published
25 Aug 2005

Chem. Commun., 2005, 4717-4719

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Nickel-catalyzed four-component connection of oraganoaluminium (organozinc), isoprene, aldehydes and amines: stereo- and regioselective synthesis of trisubstituted (E)-homoallylamines

K. Kojima, M. Kimura and Y. Tamaru, Chem. Commun., 2005, 4717 DOI: 10.1039/B507229H

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