Issue 28, 2005

Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst

Abstract

The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole 3 and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.

Graphical abstract: Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst

Supplementary files

Article information

Article type
Communication
Submitted
06 Jun 2005
Accepted
08 Jun 2005
First published
21 Jun 2005

Chem. Commun., 2005, 3586-3588

Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst

A. Córdova, W. Zou, I. Ibrahem, E. Reyes, M. Engqvist and W. Liao, Chem. Commun., 2005, 3586 DOI: 10.1039/B507968N

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