Issue 6, 2006

Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Abstract

This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.

Graphical abstract: Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Article information

Article type
Tutorial Review
Submitted
11 Apr 2006
First published
10 May 2006

Chem. Soc. Rev., 2006,35, 500-511

Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

M. Woods, D. E. Woessner and A. D. Sherry, Chem. Soc. Rev., 2006, 35, 500 DOI: 10.1039/B509907M

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