Issue 21, 2005

Oligo- and poly-nucleotides: 50 years of chemical synthesis

Abstract

It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3′→5′-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described.

Graphical abstract: Oligo- and poly-nucleotides: 50 years of chemical synthesis

Article information

Article type
Perspective
Submitted
21 Jul 2005
First published
05 Oct 2005

Org. Biomol. Chem., 2005,3, 3851-3868

Oligo- and poly-nucleotides: 50 years of chemical synthesis

C. B. Reese, Org. Biomol. Chem., 2005, 3, 3851 DOI: 10.1039/B510458K

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