Issue 9, 2007

The diverse chemistry of oxazol-5-(4H)-ones

Abstract

The assembly of structurally diverse scaffolds via substrate controlled diversity oriented synthesis (DOS) has proven to be an effective tool in the discovery of novel biologically important compounds. This tutorial review aims to summarize some of the more recent applications of oxazolones as a general template for the stereoselective syntheses of amino acids and heterocyclic scaffolds. A brief introduction covers a short history, nomenclature and general reactivity of oxazolones. The main body of this tutorial review highlights several applications of oxazolones as starting blocks for the diverse and stereoselective synthesis of amino acids, oxazoles, β-lactams, pyrroles, imidazolines, pyrrolines, and imidazoles.

Graphical abstract: The diverse chemistry of oxazol-5-(4H)-ones

Article information

Article type
Tutorial Review
Submitted
05 Oct 2006
First published
12 Mar 2007

Chem. Soc. Rev., 2007,36, 1432-1440

The diverse chemistry of oxazol-5-(4H)-ones

J. S. Fisk, R. A. Mosey and J. J. Tepe, Chem. Soc. Rev., 2007, 36, 1432 DOI: 10.1039/B511113G

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