Issue 7, 2006

Catalytic asymmetric synthesis of α- and β-amino phosphonic acid derivatives

Abstract

Catalytic asymmetric reactions provide one of the most powerful and economical synthetic approaches to a variety of enantiomerically enriched compounds. As being analogues of the corresponding α- and β-amino acids, optically active α- and β-amino phosphonic acid derivatives have found widespread use in medicinal chemistry and the pharmaceutical sciences. Using catalytic amounts of chiral materials, asymmetric synthesis of enantiomerically enriched α- and β-amino phosphonates has been a subject of growing interest. This tutorial review contains a compilation of the catalytic asymmetric synthetic methods developed to date and highlights their utility for obtaining these target compounds.

Graphical abstract: Catalytic asymmetric synthesis of α- and β-amino phosphonic acid derivatives

Article information

Article type
Tutorial Review
Submitted
22 Dec 2005
First published
10 Feb 2006

Chem. Soc. Rev., 2006,35, 630-636

Catalytic asymmetric synthesis of α- and β-amino phosphonic acid derivatives

J. Ma, Chem. Soc. Rev., 2006, 35, 630 DOI: 10.1039/B517100H

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