Issue 13, 2006
From the journal:

Chemical Communications

Nickel-catalyzed asymmetric α-arylation of ketone enolates†

Guoshu Chen,a   Fuk Yee Kwong,*a   Hoi On Chan,a   Wing-Yiu Yub  and  Albert S. C. Chan*a  

* Corresponding authors

a Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong
E-mail: bcfyk@inet.polyu.edu.hk
Fax: +(852)-23649932

b Open Laboratory of Chemical Biology and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong

Abstract

An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

Graphical abstract: Nickel-catalyzed asymmetric α-arylation of ketone enolates

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Article information

DOI
https://doi.org/10.1039/B601691J
Article type
Communication
Submitted
03 Feb 2006
Accepted
06 Feb 2006
First published
21 Feb 2006

Chem. Commun., 2006, 1413-1415

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Nickel-catalyzed asymmetric α-arylation of ketone enolates

G. Chen, F. Y. Kwong, H. O. Chan, W. Yu and A. S. C. Chan, Chem. Commun., 2006, 1413 DOI: 10.1039/B601691J

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