Issue 22, 2006
From the journal:

Dalton Transactions

A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity†

Yongmei Zhao,a   Weijiang He,*a   Pengfei Shi,a   Jianhui Zhu,a   Lin Qiu,a   Liping Linb  and  Zijian Guo*a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: zguo@nju.edu.cn, heweij69@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83594549

b State Key Laboratory for New Drug Research, Shanghai Institute of Biological Science, Shanghai, P. R. China

Abstract

A trinuclear 3N-chelated monofunctional platinum complex, [Pt3(HPTAB)Cl3](ClO4)3 (HPTAB = N,N,N′,N′,N″,N″-hexakis(2-pyridylmethyl)-1,3,5-tris(aminomethyl)benzene), has been structurally characterized, which binds to DNA and demonstrates much higher potency against the murine leukemia cell line (P-388) and the human nonsmall-cell lung cancer cell line (A-549) than cisplatin.

Graphical abstract: A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity

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Article information

DOI
https://doi.org/10.1039/B601739H
Article type
Communication
Submitted
06 Feb 2006
Accepted
16 Mar 2006
First published
27 Mar 2006

Dalton Trans., 2006, 2617-2619

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A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity

Y. Zhao, W. He, P. Shi, J. Zhu, L. Qiu, L. Lin and Z. Guo, Dalton Trans., 2006, 2617 DOI: 10.1039/B601739H

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