Issue 18, 2006

A concise synthesis of (−)-centrolobine via a diastereoselective ring rearrangement metathesis–isomerisation sequence

Abstract

A total synthesis of (−)-centrolobine (1) based on a diastereoselective ring rearrangement metathesis–double bond isomerisation sequence and a one-pot cross metathesis–hydrogenation procedure is described.

Graphical abstract: A concise synthesis of (−)-centrolobine via a diastereoselective ring rearrangement metathesis–isomerisation sequence

Article information

Article type
Communication
Submitted
13 Feb 2006
Accepted
10 Mar 2006
First published
30 Mar 2006

Chem. Commun., 2006, 1968-1970

A concise synthesis of (−)-centrolobine via a diastereoselective ring rearrangement metathesis–isomerisation sequence

V. Böhrsch and S. Blechert, Chem. Commun., 2006, 1968 DOI: 10.1039/B602056A

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