Issue 2, 2007
From the journal:

Chemical Society Reviews

Chemical double-mutant cycles: dissecting non-covalent interactions

Scott L. Cockrofta  and  Christopher A. Hunter*a  

* Corresponding authors

a Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Science, University of Sheffield, UK
E-mail: c.hunter@sheffield.ac.uk

Abstract

Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.

Graphical abstract: Chemical double-mutant cycles: dissecting non-covalent interactions

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Article information

DOI
https://doi.org/10.1039/B603842P
Article type
Tutorial Review
Submitted
24 Aug 2006
First published
27 Nov 2006

Chem. Soc. Rev., 2007,36, 172-188

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Chemical double-mutant cycles: dissecting non-covalent interactions

S. L. Cockroft and C. A. Hunter, Chem. Soc. Rev., 2007, 36, 172 DOI: 10.1039/B603842P

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