Issue 25, 2006

Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex

Abstract

We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 ± 0.9 base pairs per turn.

Graphical abstract: Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar 2006
Accepted
24 Apr 2006
First published
23 May 2006

Chem. Commun., 2006, 2675-2677

Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex

S. Rinker, Y. Liu and H. Yan, Chem. Commun., 2006, 2675 DOI: 10.1039/B603872G

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