Issue 10, 2006

A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis

Abstract

Metabonomic/metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample throughout the run, thereby enabling the analysis to be monitored and controlled using targeted inspection of the data and pattern recognition, is advocated as a pragmatic solution to this problem.

Graphical abstract: A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis

Article information

Article type
Forum
First published
15 Aug 2006

Analyst, 2006,131, 1075-1078

A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis

T. Sangster, H. Major, R. Plumb, A. J. Wilson and I. D. Wilson, Analyst, 2006, 131, 1075 DOI: 10.1039/B604498K

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