Issue 28, 2006
From the journal:

Journal of Materials Chemistry

Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging†

Stephen J. Byrne,a   Serena A. Corr,a   Tatsiana Y. Rakovich,a   Yurii K. Gun'ko,*a   Yury P. Rakovich,b   John F. Donegan,b   Siobhan Mitchellc  and  Yuri Volkovc  

* Corresponding authors

a The School of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland
E-mail: igounko@tcd.ie

b The School of Physics, Trinity College, University of Dublin, Ireland

c The Department of Clinical Medicine, Trinity College, University of Dublin, Ireland

Abstract

We report the preparation and luminescence enhancement of thioglycolic acid (TGA) stabilised CdTe quantum dots (QDs) for use as live cell imaging tools in THP-1 macrophage cells. Short irradiating times utilising a high powered Hg lamp resulted in increases in luminescence efficiencies of up to ∼40% and permit significantly enhanced live imaging of the THP-1 cellular components. It was found that the TGA-stabilised QDs traverse the cell membrane, illuminating the cytoplasm and decorating the nuclear membrane. These studies highlight the potential use of photoetched CdTe QDs as probes for specific in vitro labelling.

Graphical abstract: Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging

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Article information

DOI
https://doi.org/10.1039/B605333E
Article type
Paper
Submitted
13 Apr 2006
Accepted
23 May 2006
First published
12 Jun 2006

J. Mater. Chem., 2006,16, 2896-2902

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Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging

S. J. Byrne, S. A. Corr, T. Y. Rakovich, Y. K. Gun'ko, Y. P. Rakovich, J. F. Donegan, S. Mitchell and Y. Volkov, J. Mater. Chem., 2006, 16, 2896 DOI: 10.1039/B605333E

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