Issue 15, 2006

A concise total synthesis of salinosporamide A

Abstract

A concise and straightforward 14-step total synthesis of (±)-salinosporamide A, based on a diastereoselective acid-catalysed intramolecular cyclisation of 6 to the pyrrolidinone 7, and a regioselective reduction of the malonate derivative 8b to the aldehyde 9, is described.

Graphical abstract: A concise total synthesis of salinosporamide A

Supplementary files

Article information

Article type
Communication
Submitted
19 May 2006
Accepted
12 Jun 2006
First published
29 Jun 2006

Org. Biomol. Chem., 2006,4, 2845-2846

A concise total synthesis of salinosporamide A

N. P. Mulholland, G. Pattenden and I. A. S. Walters, Org. Biomol. Chem., 2006, 4, 2845 DOI: 10.1039/B607109K

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