Issue 7, 2007

Heterocycle synthesis by copper facilitated addition of heteroatoms to alkenes, alkynes and arenes

Abstract

The de nouvo synthesis of small organic heterocyclic molecules has benefited from recent protocols for copper-facilitated additions of heteroatoms to alkenes, alkynes and arenes. This tutorial review summarizes a number of these recent contributions. Copper salts can facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and transition metal catalysts. The current understanding of the mechanisms of these reactions is presented. This review should be of interest to chemists involved in the synthesis of heterocycles and those investigating transition metal facilitated reactions.

Graphical abstract: Heterocycle synthesis by copper facilitated addition of heteroatoms to alkenes, alkynes and arenes

Article information

Article type
Tutorial Review
Submitted
08 Nov 2006
First published
05 Feb 2007

Chem. Soc. Rev., 2007,36, 1153-1160

Heterocycle synthesis by copper facilitated addition of heteroatoms to alkenes, alkynes and arenes

S. R. Chemler and P. H. Fuller, Chem. Soc. Rev., 2007, 36, 1153 DOI: 10.1039/B607819M

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