Issue 41, 2006
From the journal:

Chemical Communications

Direct addition of alkynes to imines and related C[double bond, length as m-dash]N electrophiles: A convenient access to propargylamines

Lorenzo Zania  and  Carsten Bolm*a  

* Corresponding authors

a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Germany
E-mail: carsten.bolm@oc.rwth-aachen.de
Fax: +49 241 8092391
Tel: +49 241 8094675

Abstract

Propargylic amines are highly useful building blocks in organic synthesis, and the corresponding structural motif has been found in various natural products and compounds of pharmaceutical relevance. This article provides an overview of the most significant advances in the preparation of propargylic amines via the direct addition of alkynes to imines and related carbon–nitrogen electrophiles in the presence of metal catalysts or promoters.

Graphical abstract: Direct addition of alkynes to imines and related C [[double bond, length as m-dash]] N electrophiles: A convenient access to propargylamines

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Article information

DOI
https://doi.org/10.1039/B607986P
Article type
Feature Article
Submitted
05 Jun 2006
Accepted
11 Jul 2006
First published
25 Aug 2006

Chem. Commun., 2006, 4263-4275

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Direct addition of alkynes to imines and related C[double bond, length as m-dash]N electrophiles: A convenient access to propargylamines

L. Zani and C. Bolm, Chem. Commun., 2006, 4263 DOI: 10.1039/B607986P

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