Issue 2, 2007
From the journal:

Green Chemistry

A facile and green synthetic route to boronic acidesters utilizing mechanochemistry

Michael Schnürch,*a   Markus Holzweber,a   Marko D. Mihovilovica  and  Peter Stanetty*a  

* Corresponding authors

a Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria
E-mail: peter.stanetty@tuwien.ac.at
Fax: +43-1-58801-15499

Abstract

A facile and environmentally benign method for the formation of boronic acid esters from corresponding boronic acids is reported. Simple grinding of a 1 : 1 mixture of the boronic acid (alkyl, aryl, or heteroaryl boronic acid) and the diol (pinacol or 2,2-dimethylpropane-1,2-diol) without a solvent gave the boronic acid esters. A subsequent simple work-up step gave the title compounds in excellent yield and purity.

Graphical abstract: A facile and green synthetic route to boronic acid esters utilizing mechanochemistry

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Article information

DOI
https://doi.org/10.1039/B611424E
Article type
Paper
Submitted
08 Aug 2006
Accepted
18 Oct 2006
First published
01 Nov 2006

Green Chem., 2007,9, 139-145

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A facile and green synthetic route to boronic acid esters utilizing mechanochemistry

M. Schnürch, M. Holzweber, M. D. Mihovilovic and P. Stanetty, Green Chem., 2007, 9, 139 DOI: 10.1039/B611424E

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