Issue 1, 2007

The Heck–Mizoroki cross-coupling reaction: a mechanistic perspective

Abstract

The Heck–Mizoroki cross-coupling reaction is an important part of the synthetic chemist's toolbox, and it has been applied to a huge variety of different substrates. In contrast, the mechanism of the process is much less studied, and consequently less understood. There have been numerous studies reported over recent years, both experimental and theoretical, aimed at uncovering the inner working of this palladium-mediated coupling process. This perspective aims to review and compare these works and to provide an up-to-date view of this reaction.

Graphical abstract: The Heck–Mizoroki cross-coupling reaction: a mechanistic perspective

Article information

Article type
Perspective
Submitted
10 Aug 2006
First published
09 Nov 2006

Org. Biomol. Chem., 2007,5, 31-44

The Heck–Mizoroki cross-coupling reaction: a mechanistic perspective

J. P. Knowles and A. Whiting, Org. Biomol. Chem., 2007, 5, 31 DOI: 10.1039/B611547K

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