Issue 12, 2007

Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azidealkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution.

Graphical abstract: Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

Supplementary files

Article information

Article type
Communication
Submitted
17 Oct 2006
Accepted
14 Dec 2006
First published
15 Jan 2007

Chem. Commun., 2007, 1269-1271

Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

D. E. Prasuhn, Jr., R. M. Yeh, A. Obenaus, M. Manchester and M. G. Finn, Chem. Commun., 2007, 1269 DOI: 10.1039/B615084E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements