Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

Céline Deraeve; Marguerite Pitié; Honoré Mazarguil; Bernard Meunier

doi:10.1039/B616085A

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Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents†

Céline Deraeve,^a Marguerite Pitié,*^a Honoré Mazarguil^b and Bernard Meunier ‡^a

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* Corresponding authors

^a Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, Toulouse cedex 4, France
E-mail: pitie@lcc-toulouse.fr
Fax: +33 (0)5 55 30 03
Tel: +33 (0)5 33 32 36

^b Institut de Pharmacologie et Biologie Structurale du CNRS, 205 route de Narbonne, Toulouse cedex 4, France

Abstract

A strategy based on the use of a tetradentate ligand containing two linked 8-hydroxyquinolines allowed a significant increase in the ability to protect against β-amyloid peptide precipitation in the presence of Cu(II), Zn(II) and Fe(III) when compared to clioquinol, a 8-hydroxyquinoline derivative active in vivo.

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Supplementary files

Expected complexes, protocols and solubility of Aβ _1-42 for different ratios of Cu(II). PDF (135K)

Article information

DOI: https://doi.org/10.1039/B616085A
Article type: Letter
Submitted: 06 Nov 2006
Accepted: 19 Dec 2006
First published: 09 Jan 2007

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New J. Chem., 2007,31, 193-195

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Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

C. Deraeve, M. Pitié, H. Mazarguil and B. Meunier, New J. Chem., 2007, 31, 193 DOI: 10.1039/B616085A

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New Journal of Chemistry

Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents†

Abstract

Supplementary files

Article information

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Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

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