Issue 6, 2008

Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

Abstract

Covering: 1994 to June 2008

Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.

Graphical abstract: Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

Article information

Article type
Review Article
Submitted
21 Jul 2008
First published
30 Sep 2008

Nat. Prod. Rep., 2008,25, 1091-1117

Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

V. K. Jothivasan and C. J. Hamilton, Nat. Prod. Rep., 2008, 25, 1091 DOI: 10.1039/B616489G

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