Issue 3, 2007
From the journal:

Organic & Biomolecular Chemistry

Structural basis for cyclophellitol inhibition of a β-glucosidase

Tracey M. Gloster,a   Robert Madsenb  and  Gideon J. Davies*a  

* Corresponding authors

a York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, UK
E-mail: davies@ysbl.york.ac.uk
Fax: 44 1904 328266
Tel: 44 1904 328260

b Center for Sustainable and Green Chemistry, Department of Chemistry, Technical University of Denmark, Lyngby, Denmark
E-mail: rm@kemi.dtu.dk
Fax: 45 4588 3136
Tel: 45 4525 2151

Abstract

The structural basis for β-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.

Graphical abstract: Structural basis for cyclophellitol inhibition of a β-glucosidase

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Article information

DOI
https://doi.org/10.1039/B616590G
Article type
Communication
Submitted
13 Nov 2006
Accepted
30 Nov 2006
First published
14 Dec 2006

Org. Biomol. Chem., 2007,5, 444-446

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Structural basis for cyclophellitol inhibition of a β-glucosidase

T. M. Gloster, R. Madsen and G. J. Davies, Org. Biomol. Chem., 2007, 5, 444 DOI: 10.1039/B616590G

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