Issue 15, 2007
From the journal:

Chemical Communications

Phosphine containing oligonucleotides for the development of metallodeoxyribozymes†

Loïc Ropartz,a   Nico J. Meeuwenoord,c   Gijsbert A. van der Marel,c   Piet W. N. M. van Leeuwen,b   Alexandra M. Z. Slawina  and  Paul C. J. Kamer*a  

* Corresponding authors

a School of Chemistry, University of St. Andrews, St. Andrews, Fife, UK
E-mail: pcjk@st-andrews.ac.uk
Fax: +44 (0)1334463808
Tel: +44 (0)1334467285

b Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, The Netherlands

c Leiden Institute of Chemistry, Gorlaeus Laboratories, University of Leiden, Einsteinweg 55, Leiden, The Netherlands

Abstract

Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium catalyzed allylic nucleophilic substitution.

Graphical abstract: Phosphine containing oligonucleotides for the development of metallodeoxyribozymes

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Article information

DOI
https://doi.org/10.1039/B617871E
Article type
Communication
Submitted
07 Dec 2006
Accepted
10 Jan 2007
First published
05 Feb 2007

Chem. Commun., 2007, 1556-1558

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Phosphine containing oligonucleotides for the development of metallodeoxyribozymes

L. Ropartz, N. J. Meeuwenoord, G. A. van der Marel, P. W. N. M. van Leeuwen, A. M. Z. Slawin and P. C. J. Kamer, Chem. Commun., 2007, 1556 DOI: 10.1039/B617871E

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