Issue 30, 2007

Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfonesviaenamine activation

Abstract

Over the last decade the potential of organocatalysis has successfully been demonstrated. In particular, chiral amines such as pyrrolidine analogues have emerged as a broadly applicable class of organocatalyst for asymmetric conjugate addition viaenamine activation. This Feature Article documents the development of these catalysts, emphasizing the design and mechanistic features that supply high selectivity in asymmetric Michael reactions.

Graphical abstract: Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfonesviaenamine activation

Article information

Article type
Feature Article
Submitted
25 Jan 2007
Accepted
28 Feb 2007
First published
21 Mar 2007

Chem. Commun., 2007, 3123-3135

Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfonesviaenamine activation

S. Sulzer-Mossé and A. Alexakis, Chem. Commun., 2007, 3123 DOI: 10.1039/B701216K

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