Issue 17, 2007

Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Abstract

The high mass accuracy of FT-ICR MS combined with 15N-labelling shows that mono- and di- platinated products from the reaction of erythrocytesuperoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.

Graphical abstract: Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
07 Feb 2007
Accepted
23 Mar 2007
First published
05 Apr 2007

Chem. Commun., 2007, 1719-1721

Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

S. K. Weidt, C. L. Mackay, P. R. R. Langridge-Smith and P. J. Sadler, Chem. Commun., 2007, 1719 DOI: 10.1039/B701903C

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