Issue 15, 2007
From the journal:

Chemical Communications

Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray†

Mahesh Uttamchandani,a   Kai Liu,a   Resmi C. Panickerb  and  Shao Q. Yao*abc  

* Corresponding authors

a Department of Biological Sciences, National University of Singapore, 4 Science Drive 4, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 2925

b Department of Chemistry, National University of Singapore, Singapore

c NUS MedChem Program of the Office of the Life Sciences, National University of Singapore, Singapore

Abstract

A panel of 20 peptide vinyl sulfone probes has been synthesized and used to generate activity-based fingerprinting profiles of cysteine proteases in both gel- and microarray-based formats; the inhibitor fingerprints of representative small molecule inhibitors targeted against 4 cysteine proteases were also obtained, in high-throughput, using the same protein microarray platform.

Graphical abstract: Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B702826A
Article type
Communication
Submitted
23 Feb 2007
Accepted
06 Mar 2007
First published
15 Mar 2007

Chem. Commun., 2007, 1518-1520

Permissions

Request permissions

Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray

M. Uttamchandani, K. Liu, R. C. Panicker and S. Q. Yao, Chem. Commun., 2007, 1518 DOI: 10.1039/B702826A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements