Issue 5, 2007
From the journal:

Natural Product Reports

Evolution of enzymes and pathways for the biosynthesis of cofactors†

Gemma L. Holliday,a   Janet M. Thornton,a   Andrée Marquet,b   Alison G. Smith,c   Fabrice Rébeillé,d   Ralf Mendel,e   Heidi L. Schubert,f   Andrew D. Lawrenceg  and  Martin J. Warren*g  

* Corresponding authors

a European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
E-mail: gemma@ebi.ac.uk, thornton@ebi.ac.uk

b Department of Chemistry, Universite Pierre et Marie Curie, UMR CNRS 7613, 75252 Paris, France
E-mail: marquet@ccr.jussieu.fr

c Department of Plant Sciences, University of Cambridge, Cambridge, UK
E-mail: as25@cam.ac.uk

d Laboratoire de Physiologie Cellulaire Végétale, UMR 5168, CEA-CNRS-INRA-UJF, Institut de Recherches en Technologies et Sciences pour le Vivant, CEA-Grenoble, 38054 Grenoble Cedex 9, France
E-mail: fabrice.rebeille@cea.fr

e Department of Plant Biology, Technical University of Braunschweig, 38106 Braunschweig, Germany
E-mail: r.mendel@tu-bs.de

f Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112-5650, USA
E-mail: heidi@biochem.utah.edu

g Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent, UK

Abstract

Covering: 1945 to 2007

The evolution of metabolic pathways is discussed with reference to the biosynthesis of a number of vitamins and cofactors. Retrograde and patchwork models are highlighted and their relevance to our knowledge of pathway processes and enzymes is examined. Pathway complexity is explained in terms of the acquisition of broad specificity enzymes.

Graphical abstract: Evolution of enzymes and pathways for the biosynthesis of cofactors

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Article information

DOI
https://doi.org/10.1039/B703107F
Article type
Review Article
Submitted
21 Jun 2007
First published
12 Sep 2007

Nat. Prod. Rep., 2007,24, 972-987

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Evolution of enzymes and pathways for the biosynthesis of cofactors

G. L. Holliday, J. M. Thornton, A. Marquet, A. G. Smith, F. Rébeillé, R. Mendel, H. L. Schubert, A. D. Lawrence and M. J. Warren, Nat. Prod. Rep., 2007, 24, 972 DOI: 10.1039/B703107F

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