Issue 7, 2007

Pyridine elaboration through organometallic intermediates: regiochemical control and completeness

Abstract

Pyridines carrying heterosubstituents (such as carboxy, amido, amino, alkoxy or trifluoromethyl groups or solely individual halogen atoms) can be readily and site selectively metalated. Subsequent reaction with a suitable electrophile opens rational access to a wealth of new building blocks for the synthesis of biologically active compounds. This approach relies on organometallic methods, which are both efficacious and extremely flexible as far as the substitution site and the product structure are concerned (86 references).

Graphical abstract: Pyridine elaboration through organometallic intermediates: regiochemical control and completeness

Article information

Article type
Critical Review
Submitted
24 Apr 2007
Accepted
10 May 2007
First published
04 Jun 2007

Chem. Soc. Rev., 2007,36, 1161-1172

Pyridine elaboration through organometallic intermediates: regiochemical control and completeness

M. Schlosser and F. Mongin, Chem. Soc. Rev., 2007, 36, 1161 DOI: 10.1039/B706241A

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