Issue 30, 2007
From the journal:

Chemical Communications

The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Angel A. Núñez Magro,a   Graham R. Easthamb  and  David J. Cole-Hamilton*a  

* Corresponding authors

a EaStCHEM, School of Chemistry, University of St. Andrews, St. Andrews, Fife, Scotland, UK
E-mail: djc@st-and.ac.uk
Fax: +44 (0)1334463808
Tel: +44(0)1334463805

b Lucite International, Technology Centre, PO Box 90, Wilton, Middlesbrough, Cleveland, England, UK
E-mail: graham.eastham@lucite.com
Fax: +44 (0)1642 447119
Tel: +44 (0)1642 447109

Abstract

Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl)ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.

Graphical abstract: The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

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Article information

DOI
https://doi.org/10.1039/B706635J
Article type
Communication
Submitted
02 May 2007
Accepted
08 Jun 2007
First published
06 Jul 2007

Chem. Commun., 2007, 3154-3156

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The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

A. A. N. Magro, G. R. Eastham and D. J. Cole-Hamilton, Chem. Commun., 2007, 3154 DOI: 10.1039/B706635J

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