Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors

Tawab Dastagir; Erica S. Forzani; Ruth Zhang; Islamshah Amlani; Larry A. Nagahara; Raymond Tsui; Nongjian Tao

doi:10.1039/B707025J

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Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors†

Tawab Dastagir,^a Erica S. Forzani,^a Ruth Zhang,^b Islamshah Amlani,^b Larry A. Nagahara,^b Raymond Tsui^b and Nongjian Tao*^a

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* Corresponding authors

^a Department of Electrical Engineering, Arizona Institute for Nano-electronics, Arizona State University, Tempe, AZ 85287-5706, USA
E-mail: nongjian.tao@asu.edu
Fax: +1-480-965-8118
Tel: +1-480-965-4456

^b Embedded Systems Research Center, Motorola Labs, Tempe, AZ 85284-1806, USA

Abstract

We report the unambiguous detection of a sequence of Hepatitis C Virus (HCV) at concentrations down to the fractional pM range using Single Wall Carbon Nanotube (SWNT) Field Effect Transistor (FET) devices functionalized with Peptide Nucleic Acid (PNA).

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Supplementary files

Fabrication of SWNT devices, electrochemical breaking down of metallic tubes, conductance behavior of PNA-modified SWNT devices in buffer, DI water and air, estimation of PNA surface coverage on SWNTs, determination of PNA–RNA affinity constant; response of RNA _com on PNA-modified SWNT devices with Al ₂O ₃ passivated contacts PDF (307K)

Article information

DOI: https://doi.org/10.1039/B707025J
Article type: Communication
Submitted: 09 May 2007
Accepted: 04 Jun 2007
First published: 12 Jun 2007

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Analyst, 2007,132, 738-740

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Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors

T. Dastagir, E. S. Forzani, R. Zhang, I. Amlani, L. A. Nagahara, R. Tsui and N. Tao, Analyst, 2007, 132, 738 DOI: 10.1039/B707025J

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Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors†

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Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors

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