Issue 43, 2007
From the journal:

Dalton Transactions

Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs†§‡

Olivia R. Allen,a   Andrew L. Gott,a   John A. Hartley,c   Janet M. Hartley,c   Richard J. Knoxb  and  Patrick C. McGowan*a  

* Corresponding authors

a Department of Chemistry, University of Leeds, Leeds, UK
E-mail: p.c.mcgowan@chem.leeds.ac.uk

b Protherics PLC, Building 115, Porton Down Science Park, Salisbury, Wiltshire, UK
E-mail: r.knox@enactpharma.com

c Cancer Research UK Drug–DNA Interactions Research Group, Department of Oncology, University College London, Royal Free and University College London Medical School, Courtauld Building, 91 Riding House Street, London, UK

Abstract

A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.

Graphical abstract: Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

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Article information

DOI
https://doi.org/10.1039/B708283P
Article type
Paper
Submitted
31 May 2007
Accepted
06 Jul 2007
First published
19 Sep 2007

Dalton Trans., 2007, 5082-5090

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Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

O. R. Allen, A. L. Gott, J. A. Hartley, J. M. Hartley, R. J. Knox and P. C. McGowan, Dalton Trans., 2007, 5082 DOI: 10.1039/B708283P

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