Issue 18, 2007
From the journal:

Organic & Biomolecular Chemistry

β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

Marie-Isabel Aguilar,a   Anthony W. Purcell,b   Romila Devi,a   Rebecca Lew,a   Jamie Rossjohn,a   A. Ian Smitha  and  Patrick Perlmutter*c  

* Corresponding authors

a Department of Biochemistry & Molecular Biology, Monash University, PO Box 13d, Victoria, Australia

b Department of Biochemistry & Molecular Biology, The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia

c School of Chemistry, Monash University, PO Box 23, Victoria, Australia

Abstract

Hybrid peptides consisting of α-amino acids with judiciously placed β-amino acids show great promise as peptidomimetics in an increasing range of therapeutic applications. This reflects a combination of increased stability, high specificity and relative ease of synthesis.

Graphical abstract: β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

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Article information

DOI
https://doi.org/10.1039/B708507A
Article type
Emerging Area
Submitted
06 Jun 2007
Accepted
19 Jun 2007
First published
03 Aug 2007

Org. Biomol. Chem., 2007,5, 2884-2890

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β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

M. Aguilar, A. W. Purcell, R. Devi, R. Lew, J. Rossjohn, A. I. Smith and P. Perlmutter, Org. Biomol. Chem., 2007, 5, 2884 DOI: 10.1039/B708507A

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