Issue 42, 2007
From the journal:

Chemical Communications

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex†

Julie E. Reed,abc   Stephen Neidle*ab  and  Ramon Vilar*ac  

* Corresponding authors

a Department of Chemistry, Imperial College London, London, UK
E-mail: r.vilar@imperial.ac.uk
Fax: 44 (0)207 5941967
Tel: 44 (0)207 5941139

b CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London, UK

c Institute of Chemical Research of Catalonia (ICIQ), Avgda. Països Catalans 16, 43007 Tarragona, Spain

Abstract

Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.

Graphical abstract: Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

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Article information

DOI
https://doi.org/10.1039/B709898G
Article type
Communication
Submitted
29 Jun 2007
Accepted
26 Jul 2007
First published
13 Aug 2007

Chem. Commun., 2007, 4366-4368

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Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

J. E. Reed, S. Neidle and R. Vilar, Chem. Commun., 2007, 4366 DOI: 10.1039/B709898G

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