Issue 38, 2007
From the journal:

Chemical Communications

Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide–alkyne cycloadditions†

Tai-Shan Hu,ab   René Tannert,ab   Hans-Dieter Arndtab  and  Herbert Waldmann*ab  

* Corresponding authors

a Universität Dortmund, Fachbereich Chemie, Otto-Hahn-Str. 6, Germany

b Max-Plank-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, Germany
E-mail: herbert.waldmann@mpi-dortmund.mpg.de

Abstract

The synthesis of a focused library of jasplakinolide analogs with a 1,2,3-triazole in place of an E-configured double bond is described, featuring the Cu(I) catalyzed azide–alkyne cycloaddition reaction as an efficient macrocyclization tool.

Graphical abstract: Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide–alkyne cycloadditions

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Article information

DOI
https://doi.org/10.1039/B710650E
Article type
Communication
Submitted
11 Jul 2007
Accepted
27 Jul 2007
First published
14 Aug 2007

Chem. Commun., 2007, 3942-3944

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Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide–alkyne cycloadditions

T. Hu, R. Tannert, H. Arndt and H. Waldmann, Chem. Commun., 2007, 3942 DOI: 10.1039/B710650E

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