Issue 39, 2007
From the journal:

Chemical Communications

Highly efficient asymmetric reduction of arylpropionic aldehydes by Horse Liver Alcohol Dehydrogenase through dynamic kinetic resolution†‡

Daria Giacomini,*a   Paola Galletti,a   Arianna Quintavalla,a   Gabriele Gucciardob  and  Francesca Paradisib  

* Corresponding authors

a Department of Chemistry “G. Ciamician”, Alma Mater Studiorum University of Bologna, Via Selmi 2, Bologna, Italy
E-mail: daria.giacomini@unibo.it
Fax: +39 051 209 9456
Tel: +39 051 209 9528

b Centre for Synthesis & Chemical Biology, UCD School of Chemistry & Chemical Biology, University College Dublin, Belfield, Ireland

Abstract

The enantioselective synthesis of (2S)-2-phenylpropanol and (2S)-2-(4-iso-butylphenyl)propanol ((S)-Ibuprofenol) has been achieved by means of Horse Liver Alcohol Dehydrogenase (HLADH) in buffered aqueous solution or buffered organic solvent mixtures; under the reaction conditions, a dynamic kinetic resolution (DKR) process was realized with good reaction yields and enantiomeric ratios.

Graphical abstract: Highly efficient asymmetric reduction of arylpropionic aldehydes by Horse Liver Alcohol Dehydrogenase through dynamic kinetic resolution

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Article information

DOI
https://doi.org/10.1039/B712290J
Article type
Communication
Submitted
10 Aug 2007
Accepted
30 Aug 2007
First published
10 Sep 2007

Chem. Commun., 2007, 4038-4040

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Highly efficient asymmetric reduction of arylpropionic aldehydes by Horse Liver Alcohol Dehydrogenase through dynamic kinetic resolution

D. Giacomini, P. Galletti, A. Quintavalla, G. Gucciardo and F. Paradisi, Chem. Commun., 2007, 4038 DOI: 10.1039/B712290J

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