High yielding alkylations of unactivated sp3 and sp2 centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPr

Cory Valente; Sylvia Baglione; David Candito; Christopher J. O'Brien; Michael G. Organ

doi:10.1039/B715081D

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High yielding alkylations of unactivated sp³ and sp² centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPr†

Cory Valente,^a Sylvia Baglione,^a David Candito,^a Christopher J. O'Brien^a and Michael G. Organ*^a

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* Corresponding authors

^a Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada
E-mail: organ@yorku.ca

Abstract

High yielding, room temperature cross couplings of unactivated alkyl bromides and aryl bromides/chlorides with alkyl-9-BBN reagents has been achieved using an NHC-based catalyst (Pd-PEPPSI-IPr) via a general, functional-group tolerant and easily implemented protocol.

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Supplementary files

Experimental procedures and compound data PDF (629K)

Article information

DOI: https://doi.org/10.1039/B715081D
Article type: Communication
Submitted: 01 Oct 2007
Accepted: 23 Nov 2007
First published: 07 Dec 2007

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Chem. Commun., 2008, 735-737

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High yielding alkylations of unactivated sp³ and sp² centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPr

C. Valente, S. Baglione, D. Candito, C. J. O'Brien and M. G. Organ, Chem. Commun., 2008, 735 DOI: 10.1039/B715081D

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