DNA-templated CMV viral capsidproteins assemble into nanotubes

Yun Xu; Jian Ye; Huajie Liu; Enjun Cheng; Yang Yang; Wenxing Wang; Manchun Zhao; Dejian Zhou; Dongsheng Liu; Rongxiang Fang

doi:10.1039/B715299J

DNA-templated CMV viral capsidproteins assemble into nanotubes†

Yun Xu,‡^a Jian Ye,‡^b Huajie Liu,^a Enjun Cheng,^a Yang Yang,^a Wenxing Wang,^a Manchun Zhao,^a Dejian Zhou,^c Dongsheng Liu*^a and Rongxiang Fang^b

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^a National Centre for NanoScience & Technology, No. 11, Beiyitiao, Zhongguancun, Beijing 100080, P. R. China
E-mail: liuds@nanoctr.cn
Fax: +86-10-62656765
Tel: +86-10-82545589

^b State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China

^c School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK

Abstract

This communication describes the in vitro assembly of genetically recombinant Cucumber Mosaic Virus (CMV) viral capsidproteins (CPs) into biological nanotubes, several micrometres long yet with a diameter of only ∼17 nm, triggered by double-stranded DNAs of different lengths.

Chemical Communications

DNA-templated CMV viral capsidproteins assemble into nanotubes†

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DNA-templated CMV viral capsidproteins assemble into nanotubes

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