Issue 5, 2008
From the journal:

Natural Product Reports

Scaffold diversity of natural products: inspiration for combinatorial library design

Kristina Grabowski,a   Karl-Heinz Baringhausb  and  Gisbert Schneider*a  

* Corresponding authors

a Goethe-University, Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Siesmayerstr. 70, Frankfurt a.M., Germany
E-mail: gisbert.schneider@modlab.de

b Sanofi-Aventis Deutschland GmbH, Drug Design, Bldg. G878, Frankfurt a.M., Germany

Abstract

Covering: up to 2008

Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.

Graphical abstract: Scaffold diversity of natural products: inspiration for combinatorial library design

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B715668P
Article type
Review Article
Submitted
06 May 2008
First published
07 Jul 2008

Nat. Prod. Rep., 2008,25, 892-904

Permissions

Request permissions

Scaffold diversity of natural products: inspiration for combinatorial library design

K. Grabowski, K. Baringhaus and G. Schneider, Nat. Prod. Rep., 2008, 25, 892 DOI: 10.1039/B715668P

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements