Issue 10, 2008
From the journal:

Chemical Communications

Discovery of heparin chemosensors through diversity oriented fluorescence library approach†

Shenliang Wanga  and  Young-Tae Chang*abcd  

* Corresponding authors

a Department of Chemistry, New York University, New York, New York 10003, USA

b Department of Chemistry, National University of Singapore, Singapore 117543

c NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore 117543

d Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Singapore 138667
E-mail: chmcyt@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 6774

Abstract

Two novel heparin sensors, Heparin Orange and Heparin Blue, were developed by a diversity oriented fluorescence library approach (DOFLA) from a benzimidazolium library; the discovered compounds showed remarkable properties and have the potential to be applied to monitoring heparin levels in clinical plasma samples for point-of-care detection.

Graphical abstract: Discovery of heparin chemosensors through diversity oriented fluorescence library approach

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Article information

DOI
https://doi.org/10.1039/B717058K
Article type
Communication
Submitted
05 Nov 2007
Accepted
26 Nov 2007
First published
11 Dec 2007

Chem. Commun., 2008, 1173-1175

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Discovery of heparin chemosensors through diversity oriented fluorescence library approach

S. Wang and Y. Chang, Chem. Commun., 2008, 1173 DOI: 10.1039/B717058K

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