Issue 20, 2008

Substitution behaviour of amine-bridged dinuclear Pt(ii) complexes with bio-relevant nucleophiles

Abstract

Complexes of the type [Pt2(N,N,N′,N′-tetrakis(2-pyridylmethyl)diamine(H2O)2]4+ and [Pt2(N,N,N′,N′-tetrakis(2-pyridylmethyl)diamine(Cl)2]2+ were used to study their reactions with a series of bio-relevant nucleophiles, viz.thiourea, L-methionine and guanosine-5′-monophosphate (5′-GMP2−) as a function of nucleophile concentration and temperature. The reactions with the sulfur containing nucleophiles (thiourea and L-methionine) were followed under pseudo-first-order conditions by stopped-flow and UV-Vis spectrophotometry. The reaction with 5′-GMP2− was carried out under second order conditions and studied by NMR spectroscopy. The results indicate that the bridged dinuclear complexes remain intact after coordination of the studied nucleophiles for an extended period of time, which differs significantly from that reported for other multinuclear platinum complexes in the literature.

Graphical abstract: Substitution behaviour of amine-bridged dinuclear Pt(ii) complexes with bio-relevant nucleophiles

Supplementary files

Article information

Article type
Paper
Submitted
23 Nov 2007
Accepted
25 Feb 2008
First published
04 Apr 2008

Dalton Trans., 2008, 2759-2766

Substitution behaviour of amine-bridged dinuclear Pt(II) complexes with bio-relevant nucleophiles

H. Ertürk, J. Maigut, R. Puchta and R. van Eldik, Dalton Trans., 2008, 2759 DOI: 10.1039/B718177A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements